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authorCoprDistGit <infra@openeuler.org>2023-05-15 07:09:57 +0000
committerCoprDistGit <infra@openeuler.org>2023-05-15 07:09:57 +0000
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tree0157892a254c2c7152fdf5520d3ca0eab4684ec3
parent220ca167cfc2b89f3084b5668586eee5f98fe8a8 (diff)
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+/chromosight-1.6.3.tar.gz
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+%global _empty_manifest_terminate_build 0
+Name: python-chromosight
+Version: 1.6.3
+Release: 1
+Summary: Detect loops (and other patterns) in Hi-C contact maps.
+License: MIT
+URL: https://github.com/koszullab/chromosight
+Source0: https://mirrors.nju.edu.cn/pypi/web/packages/e5/a6/302010f5ec174023ae984e5cb76413a7cb7129a19f8b7e503699da14c52a/chromosight-1.6.3.tar.gz
+BuildArch: noarch
+
+Requires: python3-cooler
+Requires: python3-docopt
+Requires: python3-jsonschema
+Requires: python3-matplotlib
+Requires: python3-numpy
+Requires: python3-scikit-learn
+Requires: python3-scipy
+
+%description
+# Chromosight
+<img src="docs/logo/chromosight.gif" alt="animated logo" width="200"/>
+
+[![PyPI version](https://badge.fury.io/py/chromosight.svg)](https://badge.fury.io/py/chromosight) [![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg?style=flat)](http://bioconda.github.io/recipes/chromosight/README.html) [![build](https://github.com/koszullab/chromosight/actions/workflows/build.yml/badge.svg?branch=master)](https://github.com/koszullab/chromosight/actions/workflows/build.yml) [![Docker Image on Quay](https://quay.io/repository/biocontainers/chromosight/status "Docker image on Quay")](https://quay.io/repository/biocontainers/chromosight) [![codecov](https://codecov.io/gh/koszullab/chromosight/branch/master/graph/badge.svg)](https://codecov.io/gh/koszullab/chromosight) [![Read the docs](https://readthedocs.org/projects/chromosight/badge)](https://chromosight.readthedocs.io) [![License: GPLv3](https://img.shields.io/badge/License-GPL%203-0298c3.svg)](https://opensource.org/licenses/GPL-3.0) [![Language grade: Python](https://img.shields.io/lgtm/grade/python/g/koszullab/chromosight.svg?logo=lgtm&logoWidth=18)](https://lgtm.com/projects/g/koszullab/chromosight/context:python)
+
+Python package to detect chromatin loops (and other patterns) in Hi-C contact maps.
+
+* Associated publication: https://www.nature.com/articles/s41467-020-19562-7
+* Documentation and analyses examples: https://chromosight.readthedocs.io
+* scripts used for the analysis presented in the article https://github.com/koszullab/chromosight_analyses_scripts
+
+## Installation
+
+Stable version with pip:
+
+```sh
+pip3 install --user chromosight
+```
+Stable version with conda:
+```sh
+conda install -c bioconda -c conda-forge chromosight
+```
+
+or, if you want to get the latest development version:
+
+```
+pip3 install --user -e git+https://github.com/koszullab/chromosight.git@master#egg=chromosight
+```
+
+## Usage
+
+The two main subcommands of `chromosight` are `detect` and `quantify`. For more advanced use, there are two additional subcomands: `generate-config` and `list-kernels`. To get the list and description of those subcommands, you can always run:
+
+```bash
+chromosight --help
+```
+Pattern detection is done using the `detect` subcommand. The `quantify` subcommand is used to compute pattern matching scores for a list of 2D coordinates on a Hi-C matrix. The `generate-config` subcommand is used to create a new type of pattern that can then be fed to `detect` using the `--custom-kernel` option. The `list-kernels` command is used to view informations about the available patterns.
+
+### Get started
+To get a first look at a chromosight run, you can run `chromosight test`, which will download a test dataset from the github repository and run `chromosight detect` on it. You can then have a look at the output files generated.
+
+### Important options
+
+When running `chromosight detect`, there are a handful parameters which are especially important:
+
+* `--min-dist`: Minimum genomic distance from which to detect patterns. For loops, this means the smallest loop size accepted (i.e. distance between the two anchors).
+* `--max-dist`: Maximum genomic distance from which to detect patterns. Increasing also increases runtime and memory use.
+* `--pearson`: Detection threshold. Decrease to allow a greater number of pattern detected (with potentially more false positives). Setting a very low value may actually reduce the number of detected patterns. This is due to the algorithm which might merge neighbouring patterns.
+* `--perc-zero`: Proportion of zero pixels allowed in a window for detection. If you have low coverage, increasing this value may improve results.
+
+### Example
+
+To detect all chromosome loops with sizes between 2kb and 200kb using 8 parallel threads:
+```bash
+chromosight detect --threads 8 --min-dist 20000 --max-dist 200000 hic_data.cool output_prefix
+```
+
+## Options
+
+```
+
+Pattern exploration and detection
+
+Explore and detect patterns (loops, borders, centromeres, etc.) in Hi-C contact
+maps with pattern matching.
+
+Usage:
+ chromosight detect [--kernel-config=FILE] [--pattern=loops]
+ [--pearson=auto] [--win-size=auto] [--iterations=auto]
+ [--win-fmt={json,npy}] [--norm={auto,raw,force}]
+ [--subsample=no] [--inter] [--tsvd] [--smooth-trend]
+ [--n-mads=5] [--min-dist=0] [--max-dist=auto]
+ [--no-plotting] [--min-separation=auto] [--dump=DIR]
+ [--threads=1] [--perc-zero=auto]
+ [--perc-undetected=auto] <contact_map> <prefix>
+ chromosight generate-config [--preset loops] [--click contact_map]
+ [--norm={auto,raw,norm}] [--win-size=auto] [--n-mads=5]
+ [--threads=1] <prefix>
+ chromosight quantify [--inter] [--pattern=loops] [--subsample=no]
+ [--win-fmt=json] [--kernel-config=FILE] [--norm={auto,raw,norm}]
+ [--threads=1] [--n-mads=5] [--win-size=auto]
+ [--perc-undetected=auto] [--perc-zero=auto]
+ [--no-plotting] [--tsvd] <bed2d> <contact_map> <prefix>
+ chromosight list-kernels [--long] [--mat] [--name=kernel_name]
+ chromosight test
+
+ detect:
+ performs pattern detection on a Hi-C contact map via template matching
+ generate-config:
+ Generate pre-filled config files to use for detect and quantify.
+ A config consists of a JSON file describing parameters for the
+ analysis and path pointing to kernel matrices files. Those matrices
+ files are tsv files with numeric values as kernel to use for
+ convolution.
+ quantify:
+ Given a list of pairs of positions and a contact map, computes the
+ correlation coefficients between those positions and the kernel of the
+ selected pattern.
+ list-kernels:
+ Prints information about available kernels.
+ test:
+ Download example data and run loop detection on it.
+
+```
+
+## Input
+
+Input Hi-C contact maps should be in cool format. The cool format is an efficient and compact format for Hi-C data based on HDF5. It is maintained by the Mirny lab and documented here: https://open2c.github.io/cooler/
+
+Most other Hi-C data formats (hic, homer, hic-pro), can be converted to cool using [hicexplorer's hicConvertFormat](https://hicexplorer.readthedocs.io/en/latest/content/tools/hicConvertFormat.html) or [hic2cool](https://github.com/4dn-dcic/hic2cool). Bedgraph2 format can be converted directly using cooler with the command `cooler load -f bg2 <chrom.sizes>:<binsize> in.bg2.gz out.cool`. For more informations, see the [cooler documentation](https://cooler.readthedocs.io/en/latest/cli.html#cooler-load)
+
+For `chromosight quantify`, the bed2d file is a text file with at least 6 tab-separated columns containing pairs of coordinates. The first 6 columns should be `chrom start end chrom start end` and have no header. Alternatively, the output text file generated by `chromosight detect` is also accepted. Instructions to generate a bed2d file from a bed file are given [in the documentation](https://chromosight.readthedocs.io/en/stable/TUTORIAL.html#quantification).
+
+## Output
+Three files are generated by chromosight's `detect` and `quantify` commands. Their filenames are determined by the value of the `<prefix>` argument:
+ * `prefix.tsv`: List of genomic coordinates, bin ids and correlation scores for the pattern identified
+ * `prefix.json`: JSON file containing the windows (of the same size as the kernel used) around the patterns from pattern.txt
+ * `prefix.pdf`: Plot showing the pileup (average) window of all detected patterns. Plot generation can be disabled using the `--no-plotting` option.
+
+Alternatively, one can set the `--win-fmt=npy` option to dump windows into a npy file instead of JSON. This format can easily be loaded into a 3D array using numpy's `np.load` function.
+
+> Note: the p-values and q-values provided in prefix.tsv should not be used as a criterion for filtering and are only useful for ranking calls. Their values are obtained from a Pearson correlation test and could be biased due to the dependence between contact values in the window.
+
+### Contributing
+
+All contributions are welcome. We use the [numpy standard](https://numpydoc.readthedocs.io/en/latest/format.html) for docstrings when documenting functions.
+
+The code formatting standard we use is [black](https://github.com/psf/black), with --line-length=79 to follow PEP8 recommendations. We use `nose2` as our testing framework. Ideally, new functions should have associated unit tests, placed in the `tests` folder.
+
+To test the code, you can run:
+
+```bash
+nose2 -s tests/
+```
+
+### FAQ
+
+Questions from previous users are available in the [github issues](https://github.com/koszullab/chromosight/issues?q=label%3Aquestion). You can open a new issue for your question if it is not already covered.
+### Citation
+When using Chromosight in you research, please cite the pubication: https://www.nature.com/articles/s41467-020-19562-7
+
+
+%package -n python3-chromosight
+Summary: Detect loops (and other patterns) in Hi-C contact maps.
+Provides: python-chromosight
+BuildRequires: python3-devel
+BuildRequires: python3-setuptools
+BuildRequires: python3-pip
+%description -n python3-chromosight
+# Chromosight
+<img src="docs/logo/chromosight.gif" alt="animated logo" width="200"/>
+
+[![PyPI version](https://badge.fury.io/py/chromosight.svg)](https://badge.fury.io/py/chromosight) [![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg?style=flat)](http://bioconda.github.io/recipes/chromosight/README.html) [![build](https://github.com/koszullab/chromosight/actions/workflows/build.yml/badge.svg?branch=master)](https://github.com/koszullab/chromosight/actions/workflows/build.yml) [![Docker Image on Quay](https://quay.io/repository/biocontainers/chromosight/status "Docker image on Quay")](https://quay.io/repository/biocontainers/chromosight) [![codecov](https://codecov.io/gh/koszullab/chromosight/branch/master/graph/badge.svg)](https://codecov.io/gh/koszullab/chromosight) [![Read the docs](https://readthedocs.org/projects/chromosight/badge)](https://chromosight.readthedocs.io) [![License: GPLv3](https://img.shields.io/badge/License-GPL%203-0298c3.svg)](https://opensource.org/licenses/GPL-3.0) [![Language grade: Python](https://img.shields.io/lgtm/grade/python/g/koszullab/chromosight.svg?logo=lgtm&logoWidth=18)](https://lgtm.com/projects/g/koszullab/chromosight/context:python)
+
+Python package to detect chromatin loops (and other patterns) in Hi-C contact maps.
+
+* Associated publication: https://www.nature.com/articles/s41467-020-19562-7
+* Documentation and analyses examples: https://chromosight.readthedocs.io
+* scripts used for the analysis presented in the article https://github.com/koszullab/chromosight_analyses_scripts
+
+## Installation
+
+Stable version with pip:
+
+```sh
+pip3 install --user chromosight
+```
+Stable version with conda:
+```sh
+conda install -c bioconda -c conda-forge chromosight
+```
+
+or, if you want to get the latest development version:
+
+```
+pip3 install --user -e git+https://github.com/koszullab/chromosight.git@master#egg=chromosight
+```
+
+## Usage
+
+The two main subcommands of `chromosight` are `detect` and `quantify`. For more advanced use, there are two additional subcomands: `generate-config` and `list-kernels`. To get the list and description of those subcommands, you can always run:
+
+```bash
+chromosight --help
+```
+Pattern detection is done using the `detect` subcommand. The `quantify` subcommand is used to compute pattern matching scores for a list of 2D coordinates on a Hi-C matrix. The `generate-config` subcommand is used to create a new type of pattern that can then be fed to `detect` using the `--custom-kernel` option. The `list-kernels` command is used to view informations about the available patterns.
+
+### Get started
+To get a first look at a chromosight run, you can run `chromosight test`, which will download a test dataset from the github repository and run `chromosight detect` on it. You can then have a look at the output files generated.
+
+### Important options
+
+When running `chromosight detect`, there are a handful parameters which are especially important:
+
+* `--min-dist`: Minimum genomic distance from which to detect patterns. For loops, this means the smallest loop size accepted (i.e. distance between the two anchors).
+* `--max-dist`: Maximum genomic distance from which to detect patterns. Increasing also increases runtime and memory use.
+* `--pearson`: Detection threshold. Decrease to allow a greater number of pattern detected (with potentially more false positives). Setting a very low value may actually reduce the number of detected patterns. This is due to the algorithm which might merge neighbouring patterns.
+* `--perc-zero`: Proportion of zero pixels allowed in a window for detection. If you have low coverage, increasing this value may improve results.
+
+### Example
+
+To detect all chromosome loops with sizes between 2kb and 200kb using 8 parallel threads:
+```bash
+chromosight detect --threads 8 --min-dist 20000 --max-dist 200000 hic_data.cool output_prefix
+```
+
+## Options
+
+```
+
+Pattern exploration and detection
+
+Explore and detect patterns (loops, borders, centromeres, etc.) in Hi-C contact
+maps with pattern matching.
+
+Usage:
+ chromosight detect [--kernel-config=FILE] [--pattern=loops]
+ [--pearson=auto] [--win-size=auto] [--iterations=auto]
+ [--win-fmt={json,npy}] [--norm={auto,raw,force}]
+ [--subsample=no] [--inter] [--tsvd] [--smooth-trend]
+ [--n-mads=5] [--min-dist=0] [--max-dist=auto]
+ [--no-plotting] [--min-separation=auto] [--dump=DIR]
+ [--threads=1] [--perc-zero=auto]
+ [--perc-undetected=auto] <contact_map> <prefix>
+ chromosight generate-config [--preset loops] [--click contact_map]
+ [--norm={auto,raw,norm}] [--win-size=auto] [--n-mads=5]
+ [--threads=1] <prefix>
+ chromosight quantify [--inter] [--pattern=loops] [--subsample=no]
+ [--win-fmt=json] [--kernel-config=FILE] [--norm={auto,raw,norm}]
+ [--threads=1] [--n-mads=5] [--win-size=auto]
+ [--perc-undetected=auto] [--perc-zero=auto]
+ [--no-plotting] [--tsvd] <bed2d> <contact_map> <prefix>
+ chromosight list-kernels [--long] [--mat] [--name=kernel_name]
+ chromosight test
+
+ detect:
+ performs pattern detection on a Hi-C contact map via template matching
+ generate-config:
+ Generate pre-filled config files to use for detect and quantify.
+ A config consists of a JSON file describing parameters for the
+ analysis and path pointing to kernel matrices files. Those matrices
+ files are tsv files with numeric values as kernel to use for
+ convolution.
+ quantify:
+ Given a list of pairs of positions and a contact map, computes the
+ correlation coefficients between those positions and the kernel of the
+ selected pattern.
+ list-kernels:
+ Prints information about available kernels.
+ test:
+ Download example data and run loop detection on it.
+
+```
+
+## Input
+
+Input Hi-C contact maps should be in cool format. The cool format is an efficient and compact format for Hi-C data based on HDF5. It is maintained by the Mirny lab and documented here: https://open2c.github.io/cooler/
+
+Most other Hi-C data formats (hic, homer, hic-pro), can be converted to cool using [hicexplorer's hicConvertFormat](https://hicexplorer.readthedocs.io/en/latest/content/tools/hicConvertFormat.html) or [hic2cool](https://github.com/4dn-dcic/hic2cool). Bedgraph2 format can be converted directly using cooler with the command `cooler load -f bg2 <chrom.sizes>:<binsize> in.bg2.gz out.cool`. For more informations, see the [cooler documentation](https://cooler.readthedocs.io/en/latest/cli.html#cooler-load)
+
+For `chromosight quantify`, the bed2d file is a text file with at least 6 tab-separated columns containing pairs of coordinates. The first 6 columns should be `chrom start end chrom start end` and have no header. Alternatively, the output text file generated by `chromosight detect` is also accepted. Instructions to generate a bed2d file from a bed file are given [in the documentation](https://chromosight.readthedocs.io/en/stable/TUTORIAL.html#quantification).
+
+## Output
+Three files are generated by chromosight's `detect` and `quantify` commands. Their filenames are determined by the value of the `<prefix>` argument:
+ * `prefix.tsv`: List of genomic coordinates, bin ids and correlation scores for the pattern identified
+ * `prefix.json`: JSON file containing the windows (of the same size as the kernel used) around the patterns from pattern.txt
+ * `prefix.pdf`: Plot showing the pileup (average) window of all detected patterns. Plot generation can be disabled using the `--no-plotting` option.
+
+Alternatively, one can set the `--win-fmt=npy` option to dump windows into a npy file instead of JSON. This format can easily be loaded into a 3D array using numpy's `np.load` function.
+
+> Note: the p-values and q-values provided in prefix.tsv should not be used as a criterion for filtering and are only useful for ranking calls. Their values are obtained from a Pearson correlation test and could be biased due to the dependence between contact values in the window.
+
+### Contributing
+
+All contributions are welcome. We use the [numpy standard](https://numpydoc.readthedocs.io/en/latest/format.html) for docstrings when documenting functions.
+
+The code formatting standard we use is [black](https://github.com/psf/black), with --line-length=79 to follow PEP8 recommendations. We use `nose2` as our testing framework. Ideally, new functions should have associated unit tests, placed in the `tests` folder.
+
+To test the code, you can run:
+
+```bash
+nose2 -s tests/
+```
+
+### FAQ
+
+Questions from previous users are available in the [github issues](https://github.com/koszullab/chromosight/issues?q=label%3Aquestion). You can open a new issue for your question if it is not already covered.
+### Citation
+When using Chromosight in you research, please cite the pubication: https://www.nature.com/articles/s41467-020-19562-7
+
+
+%package help
+Summary: Development documents and examples for chromosight
+Provides: python3-chromosight-doc
+%description help
+# Chromosight
+<img src="docs/logo/chromosight.gif" alt="animated logo" width="200"/>
+
+[![PyPI version](https://badge.fury.io/py/chromosight.svg)](https://badge.fury.io/py/chromosight) [![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg?style=flat)](http://bioconda.github.io/recipes/chromosight/README.html) [![build](https://github.com/koszullab/chromosight/actions/workflows/build.yml/badge.svg?branch=master)](https://github.com/koszullab/chromosight/actions/workflows/build.yml) [![Docker Image on Quay](https://quay.io/repository/biocontainers/chromosight/status "Docker image on Quay")](https://quay.io/repository/biocontainers/chromosight) [![codecov](https://codecov.io/gh/koszullab/chromosight/branch/master/graph/badge.svg)](https://codecov.io/gh/koszullab/chromosight) [![Read the docs](https://readthedocs.org/projects/chromosight/badge)](https://chromosight.readthedocs.io) [![License: GPLv3](https://img.shields.io/badge/License-GPL%203-0298c3.svg)](https://opensource.org/licenses/GPL-3.0) [![Language grade: Python](https://img.shields.io/lgtm/grade/python/g/koszullab/chromosight.svg?logo=lgtm&logoWidth=18)](https://lgtm.com/projects/g/koszullab/chromosight/context:python)
+
+Python package to detect chromatin loops (and other patterns) in Hi-C contact maps.
+
+* Associated publication: https://www.nature.com/articles/s41467-020-19562-7
+* Documentation and analyses examples: https://chromosight.readthedocs.io
+* scripts used for the analysis presented in the article https://github.com/koszullab/chromosight_analyses_scripts
+
+## Installation
+
+Stable version with pip:
+
+```sh
+pip3 install --user chromosight
+```
+Stable version with conda:
+```sh
+conda install -c bioconda -c conda-forge chromosight
+```
+
+or, if you want to get the latest development version:
+
+```
+pip3 install --user -e git+https://github.com/koszullab/chromosight.git@master#egg=chromosight
+```
+
+## Usage
+
+The two main subcommands of `chromosight` are `detect` and `quantify`. For more advanced use, there are two additional subcomands: `generate-config` and `list-kernels`. To get the list and description of those subcommands, you can always run:
+
+```bash
+chromosight --help
+```
+Pattern detection is done using the `detect` subcommand. The `quantify` subcommand is used to compute pattern matching scores for a list of 2D coordinates on a Hi-C matrix. The `generate-config` subcommand is used to create a new type of pattern that can then be fed to `detect` using the `--custom-kernel` option. The `list-kernels` command is used to view informations about the available patterns.
+
+### Get started
+To get a first look at a chromosight run, you can run `chromosight test`, which will download a test dataset from the github repository and run `chromosight detect` on it. You can then have a look at the output files generated.
+
+### Important options
+
+When running `chromosight detect`, there are a handful parameters which are especially important:
+
+* `--min-dist`: Minimum genomic distance from which to detect patterns. For loops, this means the smallest loop size accepted (i.e. distance between the two anchors).
+* `--max-dist`: Maximum genomic distance from which to detect patterns. Increasing also increases runtime and memory use.
+* `--pearson`: Detection threshold. Decrease to allow a greater number of pattern detected (with potentially more false positives). Setting a very low value may actually reduce the number of detected patterns. This is due to the algorithm which might merge neighbouring patterns.
+* `--perc-zero`: Proportion of zero pixels allowed in a window for detection. If you have low coverage, increasing this value may improve results.
+
+### Example
+
+To detect all chromosome loops with sizes between 2kb and 200kb using 8 parallel threads:
+```bash
+chromosight detect --threads 8 --min-dist 20000 --max-dist 200000 hic_data.cool output_prefix
+```
+
+## Options
+
+```
+
+Pattern exploration and detection
+
+Explore and detect patterns (loops, borders, centromeres, etc.) in Hi-C contact
+maps with pattern matching.
+
+Usage:
+ chromosight detect [--kernel-config=FILE] [--pattern=loops]
+ [--pearson=auto] [--win-size=auto] [--iterations=auto]
+ [--win-fmt={json,npy}] [--norm={auto,raw,force}]
+ [--subsample=no] [--inter] [--tsvd] [--smooth-trend]
+ [--n-mads=5] [--min-dist=0] [--max-dist=auto]
+ [--no-plotting] [--min-separation=auto] [--dump=DIR]
+ [--threads=1] [--perc-zero=auto]
+ [--perc-undetected=auto] <contact_map> <prefix>
+ chromosight generate-config [--preset loops] [--click contact_map]
+ [--norm={auto,raw,norm}] [--win-size=auto] [--n-mads=5]
+ [--threads=1] <prefix>
+ chromosight quantify [--inter] [--pattern=loops] [--subsample=no]
+ [--win-fmt=json] [--kernel-config=FILE] [--norm={auto,raw,norm}]
+ [--threads=1] [--n-mads=5] [--win-size=auto]
+ [--perc-undetected=auto] [--perc-zero=auto]
+ [--no-plotting] [--tsvd] <bed2d> <contact_map> <prefix>
+ chromosight list-kernels [--long] [--mat] [--name=kernel_name]
+ chromosight test
+
+ detect:
+ performs pattern detection on a Hi-C contact map via template matching
+ generate-config:
+ Generate pre-filled config files to use for detect and quantify.
+ A config consists of a JSON file describing parameters for the
+ analysis and path pointing to kernel matrices files. Those matrices
+ files are tsv files with numeric values as kernel to use for
+ convolution.
+ quantify:
+ Given a list of pairs of positions and a contact map, computes the
+ correlation coefficients between those positions and the kernel of the
+ selected pattern.
+ list-kernels:
+ Prints information about available kernels.
+ test:
+ Download example data and run loop detection on it.
+
+```
+
+## Input
+
+Input Hi-C contact maps should be in cool format. The cool format is an efficient and compact format for Hi-C data based on HDF5. It is maintained by the Mirny lab and documented here: https://open2c.github.io/cooler/
+
+Most other Hi-C data formats (hic, homer, hic-pro), can be converted to cool using [hicexplorer's hicConvertFormat](https://hicexplorer.readthedocs.io/en/latest/content/tools/hicConvertFormat.html) or [hic2cool](https://github.com/4dn-dcic/hic2cool). Bedgraph2 format can be converted directly using cooler with the command `cooler load -f bg2 <chrom.sizes>:<binsize> in.bg2.gz out.cool`. For more informations, see the [cooler documentation](https://cooler.readthedocs.io/en/latest/cli.html#cooler-load)
+
+For `chromosight quantify`, the bed2d file is a text file with at least 6 tab-separated columns containing pairs of coordinates. The first 6 columns should be `chrom start end chrom start end` and have no header. Alternatively, the output text file generated by `chromosight detect` is also accepted. Instructions to generate a bed2d file from a bed file are given [in the documentation](https://chromosight.readthedocs.io/en/stable/TUTORIAL.html#quantification).
+
+## Output
+Three files are generated by chromosight's `detect` and `quantify` commands. Their filenames are determined by the value of the `<prefix>` argument:
+ * `prefix.tsv`: List of genomic coordinates, bin ids and correlation scores for the pattern identified
+ * `prefix.json`: JSON file containing the windows (of the same size as the kernel used) around the patterns from pattern.txt
+ * `prefix.pdf`: Plot showing the pileup (average) window of all detected patterns. Plot generation can be disabled using the `--no-plotting` option.
+
+Alternatively, one can set the `--win-fmt=npy` option to dump windows into a npy file instead of JSON. This format can easily be loaded into a 3D array using numpy's `np.load` function.
+
+> Note: the p-values and q-values provided in prefix.tsv should not be used as a criterion for filtering and are only useful for ranking calls. Their values are obtained from a Pearson correlation test and could be biased due to the dependence between contact values in the window.
+
+### Contributing
+
+All contributions are welcome. We use the [numpy standard](https://numpydoc.readthedocs.io/en/latest/format.html) for docstrings when documenting functions.
+
+The code formatting standard we use is [black](https://github.com/psf/black), with --line-length=79 to follow PEP8 recommendations. We use `nose2` as our testing framework. Ideally, new functions should have associated unit tests, placed in the `tests` folder.
+
+To test the code, you can run:
+
+```bash
+nose2 -s tests/
+```
+
+### FAQ
+
+Questions from previous users are available in the [github issues](https://github.com/koszullab/chromosight/issues?q=label%3Aquestion). You can open a new issue for your question if it is not already covered.
+### Citation
+When using Chromosight in you research, please cite the pubication: https://www.nature.com/articles/s41467-020-19562-7
+
+
+%prep
+%autosetup -n chromosight-1.6.3
+
+%build
+%py3_build
+
+%install
+%py3_install
+install -d -m755 %{buildroot}/%{_pkgdocdir}
+if [ -d doc ]; then cp -arf doc %{buildroot}/%{_pkgdocdir}; fi
+if [ -d docs ]; then cp -arf docs %{buildroot}/%{_pkgdocdir}; fi
+if [ -d example ]; then cp -arf example %{buildroot}/%{_pkgdocdir}; fi
+if [ -d examples ]; then cp -arf examples %{buildroot}/%{_pkgdocdir}; fi
+pushd %{buildroot}
+if [ -d usr/lib ]; then
+ find usr/lib -type f -printf "/%h/%f\n" >> filelist.lst
+fi
+if [ -d usr/lib64 ]; then
+ find usr/lib64 -type f -printf "/%h/%f\n" >> filelist.lst
+fi
+if [ -d usr/bin ]; then
+ find usr/bin -type f -printf "/%h/%f\n" >> filelist.lst
+fi
+if [ -d usr/sbin ]; then
+ find usr/sbin -type f -printf "/%h/%f\n" >> filelist.lst
+fi
+touch doclist.lst
+if [ -d usr/share/man ]; then
+ find usr/share/man -type f -printf "/%h/%f.gz\n" >> doclist.lst
+fi
+popd
+mv %{buildroot}/filelist.lst .
+mv %{buildroot}/doclist.lst .
+
+%files -n python3-chromosight -f filelist.lst
+%dir %{python3_sitelib}/*
+
+%files help -f doclist.lst
+%{_docdir}/*
+
+%changelog
+* Mon May 15 2023 Python_Bot <Python_Bot@openeuler.org> - 1.6.3-1
+- Package Spec generated
diff --git a/sources b/sources
new file mode 100644
index 0000000..8b55851
--- /dev/null
+++ b/sources
@@ -0,0 +1 @@
+0a53b62982e00a551ca379489d1914b0 chromosight-1.6.3.tar.gz